Description: Mitochondrial DNA Mutations in Aging, Disease and Cancer Please note: this item is printed on demand and will take extra time before it can be dispatched to you (up to 20 working days). Author(s): Keshav K. Singh Format: Paperback Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, Germany Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K ISBN-13: 9783662125113, 978-3662125113 Synopsis Many human genetic diseases associated with blood, brain, colon, ear, eye, heart, kidney, liver, muscle, and pancreas are caused by mutations in mitochondrial DNA. Mutations in DNA can result in defects of the electron transport complexes, intermediates of the tricarboxylic acid cycle and substrate transport. The clinical manifestation of these diseases often involves muscle and the nervous system. Mitochondrial DNA mutations have now been associated with aging as well as age-related degenerative diseases such as Parkinson's, Alzheimer's, and Huntington's diseases. Changes in structure, function, and a number of mitochondria play an important role in carcinogenesis. Furthermore, the role of mitochondria in the execution of programmed cell death or apoptosis has been recognized recently.
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Book Title: Mitochondrial DNA Mutations in Aging, Disease and Cancer
Author: Keshav K. Singh
Publication Name: Mitochondrial Dna Mutations in Aging, Disease and Cancer
Format: Paperback
Language: English
Publisher: Springer-Verlag Berlin AND Heidelberg Gmbh & Co. KG
Subject: Medicine, Chemistry, Biology
Publication Year: 2013
Type: Textbook
Item Weight: 748 g
Number of Pages: 412 Pages